A THYROID MODEL DESCRIBING KINETICS OF EXCHANGE, CONCENTRATING, AND ORGANIC BINDING OF IODIDE

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Abstract
IN MODELS describing the kinetics of accumulation of radioiodine by thyroid tissue it has been assumed that the equilibration of radioiodide between blood and thyroid tissue is instantaneous (Myant, Pochin and-Goldie, 1949; Oddie, 1949; Brownell, 1951; Riggs, 1952; Wollman, 1953). However, recent measurements show that the equilibration is not instantaneous in the mouse (Wollman and Scow, 1953). In addition, the following simple calculation shows that the equilibration must be expected to take an appreciable length of time if the ratio of the radioiodide concentrations in thyroid gland and serum (T/S ratio) is large. The T/S ratio has been found to be approximately 250 in the normal mouse (Wollman and Scow, 1953). This implies that at equilibrium the radioiodide content of the thyroid is 250 times that of an equal volume of serum or (approximately) blood. If one assumes that the radioiodide concentration in the blood of the mouse is held constant after injection

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