PRODUCTION OF RUNT DISEASE IN TOLERANT MICE BY THE INJECTION OF SYNGENEIC LYMPHOID CELLS

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Abstract
Classic runting is induced in immunologically incompetent mice by the administration of viable lymphoid cells from a donor strain differing at a strong histocompatibility locus. In these experiments we explored the possibility of inducing runting with syngeneic cells in mice chimeric as a result of allogeneic cell administration at birth and demonstrably tolerant of skin from that other strain. Such runting was induced by A cells in A mice tolerant of (A X C57BL/1)F1 tissue, and by C3H cells in irradiated C3H mice tolerant of A tissue. In the latter combination, runting did not ensue when tolerance had been induced with cell-free antigenic preparations. Normal A mice injected intravenously with large numbers of (A X C57BL/l)F1 hybrid spleen cells showed no ill effects. We concluded that runting occurs when the immunologic attack is directed against lymphoid and hematopoietic cells which have become established in host tissues.