The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp.
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (12) , 1553-1558
- https://doi.org/10.7164/antibiotics.43.1553
Abstract
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp., have been deduced to be I, II and III, respectively, on the basis of spectroscopic and H-1 and C-13 NMR spectral data. The molecular structure of atpenin A4 with absolute configurations was finally confirmed to be 2'S,4'S,5'S-5,6-dimethoxy-4-hydroxy-5'-chloro-2',4',-dimethyl-1'-oxoheptyl-2-hydroxypyridine (I') by the single crystal X-ray crystallographic analysis. The absolute configurations of atpenins A5 and B were also expected to be 2'S,4'S,5'R-II(II') and 2'S,4'R-III(III'), respectively.This publication has 6 references indexed in Scilit:
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