Serum immunosuppressive acidic protein in adult T‐cell leukaemia (ATL)

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Abstract
The availability of serum immunosuppressive acidic protein (IAP) as a marker of subtypes of adult T-cell leukemia (ATL) was examined. Serum IAP levels were measured in 34 patients with ATL (18 typical, 9 atypical and 7 smouldering), 7 healthy carriers of ATLA antibody and 53 healthy controls. The mean value of serum IAP was significantly higher in patients with typical ATL (897.8 .+-. 502.4 .mu.g/ml) than in those with atypical ATL (426.7 .+-. 106.6 .mu.g/l), smoldering ATL (310.0 .+-. 51.3 .mu.g/ml), healthy carriers of ATLA antibody (302.9 .+-. 39.5 .mu.g/ml) and normal controls (350.5 .+-. 73.2 .mu.g/ml). Serial determinations of IAP revealed that the level was correlated with the clinical course in patients with ATL; there was a difference in the prognosis of patients with high and normal levels of IAP (P < 0.05). Routine measurement of serum IAP seems useful in differentiating typical, atypical and smoldering ATL and also in evaluating the prognosis of patients.