Salvage Chemotherapy with ABVD in MOPP-Resistant Hodgkin's Disease

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Abstract
Fifty-five consecutive patients with advanced recurrent Hodgkin''s disease resistant to MOPP chemotherapy (mechlorethamine, vincristine, procarbazine and prednisone) were given ABVD chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine). In 54 patients evaluable for response, complete remission after pathologic restaging was seen in 59% and partial remission in 13%. Fifteen of 29 patients (52%) showing disease progression during primary MOPP treatment achieved complete remission after ABVD. The median time to complete response was 3 mo. The median duration for complete remission was 17 mo.; 38% of patients who attained complete remission have remained alive and continuously disease free at 5 yr from start of ABVD treatment. The median survival of complete responders was more than 60 mo. Toxic manifestations were moderate, aside from pronounced vomiting in 1/2 of patients. ABVD evidently is an effective salvage regimen for MOPP-resistant Hodgkin''s disease.