Neuropathologic Observations in Electrolyte-induced Myelinolysis in the Rat

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Abstract
A recent analysis of a group of patients with central pontine myelinolysis (CPM) disclosed that a rapid rise in serum sodium from a hyponatremic baseline preceded the clinical onset of the disorder. To test the view that electrolyte derangements may be crucial in the pathogenesis of CPM, rats were given hypertonic saline following a three-day period of hyponatremia. Symmetrical, predominantly demyelinative lesions were found in the neocortex, claustrum, corpus striatum, external capsule, anterior commissure, hippocampus and its fimbria, thalamus, brainstem tegmentum, and superior vermis of the cerebellum. This report details the histopathology and topography of these lesions and compares them with human CPM. The findings support the view that a rapid rise in serum sodium may be responsible for the development of CPM in man.