Variable mapping of structure-activity relationships: Application to 17-spirolactone derivatives with mineralocorticoid activity
- 1 December 1995
- journal article
- research article
- Published by Elsevier in Journal of Molecular Graphics
- Vol. 13 (6) , 356-367
- https://doi.org/10.1016/0263-7855(95)00079-8
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- Development of specific bioluminescent In vitro assays for selecting potential antimineralocorticoidsThe Journal of Steroid Biochemistry and Molecular Biology, 1994
- Synthesis of new 11.beta.-substituted spirolactone derivatives. Relationship with affinity for mineralocorticoid and glucocorticoid receptorsJournal of Medicinal Chemistry, 1993
- Aldosterone antagonists. 4. Synthesis and activities of steroidal 6,6-ethylene-15,16-methylene 17-spirolactonesJournal of Medicinal Chemistry, 1991
- The application of molecular similarity calculationsJournal of Computational Chemistry, 1990
- The mechanism of action of steroid antagonists: Insights from crystallographic studiesJournal of Steroid Biochemistry, 1988
- Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivativesJournal of Medicinal Chemistry, 1987
- Affinity of corticosteroids for mineralocorticoid and glucocorticoid receptors of the rabbit kidney: Effect of steroid substitutionJournal of Steroid Biochemistry, 1986
- On the significance of clusters in the graphical display of structure-activity dataJournal of Medicinal Chemistry, 1986
- Molecular details of receptor binding and hormonal action of steroids derived from X-ray crystallographic investigationsJournal of Steroid Biochemistry, 1981
- Steroid hormone receptors and pharmacologyJournal of Steroid Biochemistry, 1980