Chromosome abnormalities in acute promyelocytic leukemia (APL)
Open Access
- 1 February 1979
- Vol. 43 (2) , 558-562
- https://doi.org/10.1002/1097-0142(197902)43:2<558::aid-cncr2820430223>3.0.co;2-6
Abstract
Sixteen patients, 15 adults and one child, with APL have been studied cytogenetically; 14 of these had an abnormal karyotype (87%). Eleven of these consistently showed a t(15;17)(q26;q22) structural anomaly, one patient showed a 47,+8 karyotype, one a rearrangement of chromosomes #15 and #17, apparently different from that in the other patients, and one a #17 deletion without a demonstrable translocation. As an additional chromosome change trisomy #8 was found in 5 cases and monosomy #7 in two. The t(15;17)(q26;q22) structural anomaly is highly characteristic of APL, is found in APL of children and adults, but it is apparently not associated with a clinically different form of APL. Cancer 43:558–562, 1979.Keywords
This publication has 3 references indexed in Scilit:
- 15/17 TRANSLOCATION IN ACUTE PROMYELOCYTIC LEUKÆMIAThe Lancet, 1977
- 15/17 TRANSLOCATION, A CONSISTENT CHROMOSOMAL CHANGE IN ACUTE PROMYELOCYTIC LEUKAEMIAThe Lancet, 1977
- Partial Deletion of Long Arm of Chromosome 17Archives of internal medicine (1960), 1976