The Composition of Rat Skin Surface Lipids. Analysis of the Saponifiable and Nonsaponifiable Fractions.

Abstract
The alkaline hydrolysis products of skin surface fat of normal rat have been analyzed in detail by combination of thin-layer chromatography and gas-liquid chromatography. Homologue series of C14-C34 straight and branched chain saturated as well as straight chain unsaturated fatty acids and aliphatic mono-hydric alcohols with maximum concentrations at C20:1 and C24:1, respectively, are present. There are also smaller amounts of mono-hydroxy fatty acids and alkane diols with C16-compounds as the major components. In addition to cholesterol as the chief representant, also other sterols are found and tentatively identified as lanosterol, agno-sterol, methosterol, desmosterol and lathosterol.