Epinephrine Reduction of Heme: Implication for Understanding the Transmission of an Agonist Stimulus
- 1 January 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4528) , 71-73
- https://doi.org/10.1126/science.6274020
Abstract
Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.This publication has 13 references indexed in Scilit:
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