Quantitative Structure‐Activity Relationship Studies on a New Class of Antihypertensive Agents: Derivatives of 3‐Aryl‐4,5,6,7‐tetrahydro‐1H‐pyrazolo[4,3‐c]pyridine

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Abstract
The quantitative structure‐activity relationship (QSAR) has been studied for the derivatives of 3‐aryl‐4,5,6,7‐tetrahydropyrazolo[4,3‐c]pyridine for their in vitro ability to displace [3H]prazosin. The physicochemical parameters, hydrophobic (π), and electronic (σ), and the structural parameter, van der Waals volume (Vw) are found to be significantly correlated with the displacement activity of these compounds.