Mechanisms of lymphocyte killing by HIV
- 1 January 1997
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Hematology
- Vol. 4 (1) , 24-31
- https://doi.org/10.1097/00062752-199704010-00005
Abstract
One of the remaining mysteries of HIV infection is what causes the destruction of the CD4+ T cells. Several reports in the past year have linked viral load to disease progression, strengthening the conclusion that the virus is responsible for CD4+ T-cell depletion. We discuss several possible mechanisms of T-cell death, including the killing of uninfected CD4+ T cells. We also discuss the possibility that the virus protects the cell it infects at least until viral replication can be completed.Keywords
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