Combined Use of Carboxyl-Directed Protein Pegylation and Vector-Mediated Blood-Brain Barrier Drug Delivery System Optimizes Brain Uptake of Brain-Derived Neurotrophic Factor Following Intravenous Administration
- 1 January 1998
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 15 (4) , 576-582
- https://doi.org/10.1023/a:1011981927620
Abstract
Purpose. Peptide drug delivery to the brain requires optimization of (a) plasma pharmacokinetics and (b) blood-brain barrier (BBB) permeability. In the present studies, plasma pharmacokinetics are...Keywords
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