Salicylate: A Structure-Activity Study of its Effects on Membrane Permeability
- 30 June 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4042) , 1423-1425
- https://doi.org/10.1126/science.176.4042.1423
Abstract
Salicylate and benzoate, and their analogs, reversibly increase the membrane potential and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pK a values.Keywords
This publication has 7 references indexed in Scilit:
- Partition coefficients and their usesChemical Reviews, 1971
- Salicylate: Effect on Membrane Permeability of Molluscan NeuronsScience, 1971
- Electrical Transmission among Neurons in the Buccal Ganglion of a Mollusc, Navanax inermis The Journal of general physiology, 1970
- Biological Membranes: The Physical Basis of Ion and Nonelectrolyte SelectivityAnnual Review of Physiology, 1969
- The effect of intramolecular bydrophobic bonding on partition coefficientsThe Journal of Organic Chemistry, 1967
- A New Substituent Constant, π, Derived from Partition CoefficientsJournal of the American Chemical Society, 1964
- A Reëxamination of the Hammett Equation.Chemical Reviews, 1953