Presenilin 1 is essential for cardiac morphogenesis
Open Access
- 9 June 2004
- journal article
- patterns and-phenotypes
- Published by Wiley in Developmental Dynamics
- Vol. 230 (4) , 795-799
- https://doi.org/10.1002/dvdy.20098
Abstract
Presenilin 1 (PS1) is the gene responsible for the development of early-onset familial Alzheimer's disease. PS1-deficient mice have been reported to show defects in neurogenesis, somitogenesis and angiogenesis. Here, we report cardiac anomaly in PS1-deficient mice: the mutant hearts exhibited ventricular septal defect, double outlet right ventricle, and stenosis in the pulmonary artery. Immunohistochemistry using anti-PS1 antibody revealed the prominent expression of PS1 in mesenchymal cells at the septal area of the wild-type heart. These results suggest that PS1 may play an essential role in heart development. Developmental Dynamics 230:795–799, 2004.Keywords
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