Chlorpropamide-Induced Immune Hemolytic Anemia

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Abstract
Acute intravascular hemolysis developed while a patient was taking the oral sulfonylurea, chlorpropamide. An IgG antibody was present in the patient's serum that in the presence of chlorpropamide and fresh serum, brought about the lysis of complement-sensitive red cells from patients with paroxysmal nocturnal hemoglobinuria. The antibody was found to cross-react with other sulfonylureas but not with sulfisoxazole. Red cells from some patients with paroxysmal nocturnal hemoglobinuria were not lysed by this "innocent-bystander" reaction.