Synthesis of 19-functionalised derivatives of 16α-hydroxy-testosterone: mechanistic studies on oestriol biosynthesis
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1078-1080
- https://doi.org/10.1039/c39850001078
Abstract
The 19-hydroxy and 19-oxo derivatives of 16α,17β-dihydroxy-androst-4-en-3-one (9a) have been synthesised and shown to be intermediates in the biosynthesis of oestriol in the human placenta; O2 is incorporated into formic acid released from C-19 of the 19-oxo compound (9b).Keywords
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