Macromolecular structure determination by cryo-electron microscopy
Open Access
- 1 October 2000
- journal article
- research article
- Published by International Union of Crystallography (IUCr) in Acta Crystallographica Section D-Biological Crystallography
- Vol. 56 (10) , 1215-1222
- https://doi.org/10.1107/s0907444900010787
Abstract
Recent advances in transmission electron microscopy (EM) hardware, low-temperature methods and image-processing software have made cryo-EM an important complement to X-ray crystallography and NMR for macromolecular structure determination, particularly of large assemblies. This review provides a summary of the main advances and a survey of the capabilities of this approach.Keywords
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