G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort
- 7 September 2005
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 20 (12) , 1653-1655
- https://doi.org/10.1002/mds.20682
Abstract
LRRK2 mutations have recently been described in families with Parkinson's disease. Here we show that one of them (G2019S) is present in 6% (7 of 124) unrelated cases of disease in a clinic‐based sample series from central Portugal, but not present in 126 controls from the same population. Thus, LRRK2 mutations appear to be a common cause of typical Parkinson's disease and as such will alter clinical practice. © 2005 Movement Disorder SocietyKeywords
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