Effects of Different Ionizing Radiations on Human Cells in Tissue Culture: IV. Modification of Radiation Damage

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Abstract
Modification by various treatments of radiation-induced damage in kidney cells of human origin has been investigated with 250-kvp X-rays and [alpha] -radiation from Po210. The capacity for clone formation as a function of the radiation dose was influenced significantly by the time interval between plating and irradiation, the temperature at which the cells were maintained before and after irradiation, fractionation of the dose, and the presence of oxygen, cysteamine, and glycerol. The modification of the response was much more important after sparsely ionizing 250-kvp X-radiation than with densely ionizing a -radiation from Po210. The differences between the effects of these radiations is explained on the basis of the differences in spatial distribution of the energy deposition.

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