Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria

Abstract
Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms. A role of Helicobacter pylori bacterium infection in the aetiopathogenesis of rosacea or chronic urticaria has been suggested although still controversial. The aim of the present study was to establish a relationship between H. pylori infection and rosacea chronic urticaria by means of an immunoproteomic investigation. We analyzed immunoglobulin A (IgA)‐, IgG‐, and IgE‐mediated immune‐responses against H. pylori antigens and we identified some bacterial immunoresponsive proteins. A general IgA‐ and IgE‐mediated immune response against antioxidative bacterial proteins was observed. A correlation between the bacterial occurrence and skin diseases pathogenesis is discussed.