Reaction mechanism of flavin‐dependent hydroxylation
- 1 October 1983
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 135 (3) , 543-548
- https://doi.org/10.1111/j.1432-1033.1983.tb07686.x
Abstract
Analysis of the partially refined X-ray crystallographic structure of the active site of p-hydroxybenzoate hydroxylase shows clearly that the enzyme is complementary to a flavin C4,C4a-dioxetane derivative. A mechanism is proposed based on such an intermediate as the oxenoid transferring agent. A non-enzymatic analog of this reaction is not known in organic chemistry. A possible evolutionary pathway for such a non-imitable enzyme is discussed.This publication has 20 references indexed in Scilit:
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