Molecular Characterization of β-Thalassehia in the United Arab Emirates
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 17 (4) , 355-362
- https://doi.org/10.3109/03630269308997488
Abstract
This study is to identify the various beta-thalassemic alleles in the United Arab Emirates (UAE), and compare them with the UAE residents from neighboring countries suffering from the same problem. Gene amplification, dot-blot hybridization with synthetic probes, restriction enzyme analyses, and sequencing were the tools used. Thirteen different mutations were observed in the UAE patients and seventeen mutations in the non-locals. The IVS-I-5 (G-->C) Asian Indian mutation was the most frequent mutation in both groups. Homozygous mutations in both groups were relatively higher than double heterozygous mutations.Keywords
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