Abstract
N-methane-sulfonyl-isoindolines substituted in the carbocyclic moiety can be prepared from the corresponding 1,2-bis-[brommethyl]benzenes and methane sulfonamid by cyclisation under basic conditions. The title compounds are interesting precursors for the generation of carbocyclic substituted 2H-isoindoles via base catalysed 1,2-elimination of methane sulfinic acid. By this reaction sequence the sulfonyl residue is simultaneously involved as a protecting group and as a leaving group.

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