The Selection of Gas Chromatographic Stationary Phases and Operating Conditions for the Separation and Quantitation of Heroin and Structurally Related Compounds
- 1 May 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 19 (5) , 227-234
- https://doi.org/10.1093/chromsci/19.5.227
Abstract
The limitations inherent in the analysis of heroin and some related narcotics using gas-liquid chromatography are discussed. A survey was made of stationary phases, and their suitability for quantitative analysis in conjunction with a flame ionisation detector was assessed in terms of (A) their ability to separate heroin, codeine, acetylcodeine, morphine, and 6-acetylmorphine and (B) the reproducibility of retention times and losses of the compounds by adsorption. Both conventional and modified liquid phases were studied and OV-210 was found to be the most suitable. A number of mixures of the above narcotics and caffeine were prepared and quantitatively analysed to demonstrate the reliability of the method.Keywords
This publication has 0 references indexed in Scilit: