The Melanosome: An Ideal Model to Study Cellular Differentiation
- 13 May 2003
- journal article
- Published by Wiley in Pigment Cell Research
- Vol. 16 (3) , 237-244
- https://doi.org/10.1034/j.1600-0749.2003.00034.x
Abstract
Melanosomes provide an intriguing model for study at many levels. In part this is due to their unique structure and function, but also in part to their involvement in pigmentary diseases and as a model to study basic cellular mechanisms of organelle biogenesis. Recent studies have elucidated the full proteome of the melanosome and the metabolic and molecular lesions involved in a number of pigmentary diseases have been resolved. This paper summarizes recent advances in the field in these areas.Keywords
This publication has 49 references indexed in Scilit:
- New insights into ocular albinism type 1 (OA1): Mutations and polymorphisms of the OA1 geneHuman Mutation, 2002
- Oculocutaneous albinism types 1 and 3 are ER retention diseases: mutation of tyrosinase or Tyrp1 can affect the processing of both mutant and wild‐type proteinsThe FASEB Journal, 2001
- Rab3a and SNARE Proteins: Potential Regulators of Melanosome MovementJournal of Investigative Dermatology, 2001
- Regulation of the Catalytic Activity of Preexisting Tyrosinase in Black and Caucasian Human Melanocyte Cell CulturesExperimental Cell Research, 2001
- Aberrant pH of Melanosomes in Pink-Eyed Dilution (p) Mutant MelanocytesJournal of Investigative Dermatology, 2000
- Binding and cAMP Studies of Melanotropin Peptides with the Cloned Human Peripheral Melanocortin Receptor, hMC1RBiochemical and Biophysical Research Communications, 1994
- Identification of a cDNA Coding for a Ca2+-Binding Phosphoprotein (p90), Calnexin, on Melanosomes in Normal and Malignant Human MelanocytesExperimental Cell Research, 1993
- Lysosome-Associated Membrane Protein-1 (LAMP-1) Is the Melanocyte Vesicular Membrane Glycoprotein Band IIJournal of Investigative Dermatology, 1993
- UVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System.Journal of Investigative Dermatology, 1989
- The Melanosome: A Distinctive Subcellular Particle of Mammalian Melanocytes and the Site of Melanogenesis1Journal of Investigative Dermatology, 1961