N-Hydroxylation
- 1 January 1971
- journal article
- review article
- Published by Taylor & Francis in Xenobiotica
- Vol. 1 (4-5) , 327-338
- https://doi.org/10.3109/00498257109041497
Abstract
1. Many drugs and foreign compounds contain nitrogen. Biological N-oxidation occurs with many types of N-containing compounds. 2. In mammals N-oxidation is catalyzed by enzyme systems in the endoplasmic reticulum of the liver and other tissues. Different mechanisms are involved in the N-hydroxylation of primary arylamines and the N-oxidation of secondary and tertiary amines. 3. Experimental data on the effects of stimulation and inhibition on microsomal N-oxidation of different types of amines are presented. 4. Kinetic parameters and pitfalls in experimental techniques of biological N-oxidation reactions are discussed.Keywords
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