Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B
- 9 June 2000
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 2 (7) , 435-440
- https://doi.org/10.1038/35017072
Abstract
The retinoid–X receptor (RXR) regulates multiple hormonal pathways through heterodimerization with nuclear receptors such as the all-trans retinoic acid receptor (RAR). The orphan nuclear receptor NGFI-B (also called Nur77) can heterodimerize with RXR. Here we show that nerve growth factor (NGF) induces the phosphorylation of Ser 105 of NGFI-B in PC12 phaeochromocytoma cells, resulting in translocation of the NGFI-B–RXR heterodimer complex out of the nucleus using nuclear export signals within NGFI-B. As a consequence of the redistribution of RXR, the transcriptional activity of RXR–RAR is reduced. NGFI-B-mediated nuclear export of receptors may serve as a mechanism for crosstalk between NGF and retinoid pathways.Keywords
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