Hemoglobin Switching in Sheep and Goats: Occurrence of Hemoglobins A and C in the Same Red Cell
- 13 September 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 185 (4155) , 946-948
- https://doi.org/10.1126/science.185.4155.946
Abstract
Sheep and goats switch from the synthesis of hemoglobin A (α2β2A) to hemoglobin C (α2β2C) when made anemic. We have demonstrated the existence of the asymmetrical hybrid hemoglobin, α2βAβC, in the circulating red cells of anemic sheep. These erythroid cells, therefore, synthesized both A and C hemoglobin simultaneously. Thus, the switch appears to be mediated by selective gene expression rather than by a clonal or cellular selective mechanism.Keywords
This publication has 13 references indexed in Scilit:
- Asymmetrical hemoglobin hybrids. Approach to the study of subunit interactionsBiochemistry, 1974
- Activation of Hemoglobin C Synthesis in Sheep Marrow CultureScience, 1973
- The anemia-induced reversible switch from hemoglobin A to hemoglobin C in caprine ruminants: Immunochemical evidence that both hemoglobins are found in the same cellDevelopmental Biology, 1973
- Observation of the Dissociation of Unliganded HemoglobinJournal of Biological Chemistry, 1972
- Gene Selection in Hemoglobin and in Antibody-Synthesizing CellsScience, 1972
- Dissociation of hemoglobin into subunits: Monomer formation and the influence of ligandsJournal of Molecular Biology, 1971
- GENETIC VARIATION IN THE SHEEP RED BLOOD CELLBiological Reviews, 1971
- The separation of human and animal hemoglobins by isoelectric focusing in polyacrylamide gelBiochimica et Biophysica Acta (BBA) - Protein Structure, 1971
- Hemoglobin C in Newborn Sheep and Goats: A Possible Explanation for its Function and BiosynthesisPediatric Research, 1969
- Erythropoietic kinetics in sheep studied by means of induced changes in hemoglobin phenotypeJournal of Clinical Investigation, 1968