Use of absorbed antisera for demonstration of antigenic variation among strains of Legionella pneumophila serogroup 1

Publisher Website
Google Scholar
Abstract
Selective absorption of rabbit antibodies produced against 5 strains of Lp1 [L. pneumophila serogroup 1] resulted in the recognition of 17 somatic types among the 176 strains tested. A comparison was made of theses results and those obtained by McKinney et al., and Joly et al., who used monoclonal antibodies to subgroup Lp1 strains. Antigens were present in Lp1 strains that were undetected by both systems. The data presented in this study may be helpful in selecting strains for the production of additional monoclonal or absorbed antibodies for diagnostic purposes or epidemiological studies.