Coagulation Abnormalities following Intensive Plasma Exchange on the Cell Separator

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Abstract
The effects of intensive plasma exchange on the circulating levels of coagulation factors I, II, V, VII, VIII, IX, X and antithrombin III were determined [in humans]. During courses of daily exchange marked cumulative reductions of coagulation factors may occur, particularly in the case of factors I, II and X, although usually remaining above the levels considered adequate for hemostasis. The extent of cumulative reduction and subsequent recovery differed for patients with different diseases. While antithrombin III levels were reduced during plasma exchange, this may be partly due to consumption as well as physical removal. The very low incidence of hemorrhagic sequelae and absence of thrombotic events following plasma exchange explained by the maintenance of adequate levels of coagulation factors and of antithrombin III even during courses of daily plasma exchange.