Brain iron uptake and homeostatic mechanisms: An overview
Top Cited Papers
- 1 January 2003
- journal article
- review article
- Published by Springer Nature in BioMetals
- Vol. 16 (1) , 63-75
- https://doi.org/10.1023/a:1020718718550
Abstract
Timely and adequate iron acquisition by the brain is essential to normal neurological function. Despite the numerous cognitive and neurological impairments that are associated with disruptions in brain iron acquisition, including both too much and too little iron, the mechanism and regulation of the mechanisms by which the brain acquires iron are poorly understood. In this article, we review the current state of knowledge regarding expression of iron transport proteins in the brain, brain iron uptake and discuss why a model for brain iron uptake must take into consideration the potentially competing influences on the endothelial cell between the status of iron in the brain versus the systemic iron status.Keywords
This publication has 11 references indexed in Scilit:
- A case of neuroferritinopathyTrends in Neurosciences, 2001
- Cellular distribution of iron in the brain of the Belgrade ratNeuroscience, 1999
- Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brainsJournal of the Neurological Sciences, 1999
- Developmental profile of non-heme iron distribution in the rat brain during ontogenesisDevelopmental Brain Research, 1995
- Hallervorden-Spatz Syndrome and Brain Iron MetabolismArchives of Neurology, 1991
- Receptor‐mediated transcytosis of transferrin across the blood‐brain barrierJournal of Neuroscience Research, 1987
- Cognitive deficits in iron-deficient and iron-deficient anemic childrenThe Journal of Pediatrics, 1986
- Proteins in Cerebrospinal Fluid and Plasma of Fetal Pigs during DevelopmentDevelopmental Neuroscience, 1982
- Citrate and alpha‐ketoglutarate in cerebrospinal fluid and bloodNeurology, 1971
- The Development of the Blood-Brain BarrierPublished by Elsevier ,1968