Differences in Antibody Responses of Mouse Strains to Enterobacterial Common Antigen

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Abstract
The genetic influence of various mouse strains on antibody response to the common antigen (CA) of Enterobacteriaceae was determined. Four strains of mice, three inbred and one random-bred, were injected ip with CA of E. coli 014 or 0111, with or without incomplete Freund's adjuvant. CA antibody titers, determined by hemagglutination tests, revealed the following: CBA/St and C57BL/6Ha mice responsed significantly better than did DBA/2Jax and Swiss albino mice; ethanol-soluble CA from E. coli 0111 was a better immunogen than was CA from E: cold 014; adjuvant did not enhance immunogenicity of CA in responding mice; highest titers were noted 5 days after the third injection of CA, persisted for 2 weeks, and declined by the end of 2 months; and a subsequent injection of CA failed to elicit a secondary response.

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