Normalizing Effect of an Adrenocorticotropic Hormone (4-9) Analog ORG 2766 on Disturbed Social Behavior in Rats
- 2 September 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4614) , 960-962
- https://doi.org/10.1126/science.6308767
Abstract
Short-term isolation increased the frequency of social interactions in rats tested in pairs, while pairs of rats placed in an unfamiliar test cage and subjected to a high level of illumination spent less time in active social contact. These changes in social behavior elicited by environmental manipulations were counteracted by treatment with the adrenocorticotropic hormone (4-9) analog ORG 2766. The peptide's normalizing effect may be mediated by endogenous opioid systems.This publication has 23 references indexed in Scilit:
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