Acanthosis nigricans and pituitary tumors. Report of eight cases

Publisher Website
Google Scholar
Abstract
Findings in eight patients with acanthosis nigricans and pituitary tumors, 7 of whom had acromegaly or gigantism, emphasize the association of this dermatosis with pituitary disease. The sex incidence was equal, and their ages varied between 15 and 46 yr. Two male patients had diabetes mellitus; 3 of 4 female patients had hypertrichosis, and all 4 female patients had amenorrhea. Obesity was not a constant feature. The clinical and histological findings were similar to those in acanthosis nigricans associated with other diseases. The occurrence of acanthosis nigricans with pituitary tumors as well as with other endocrine diseases, drugs, and total lipodystrophy raises the question of a possible hormonal or metabolic relationship of this derraadrome.