15(PARA-[I-123]IODOPHENYL)PENADECANOIC ACID AS TRACER OF LIPID-METABOLISM - COMPARISON WITH [1-C-14] PALMITIC ACID IN MURINE TISSUES

  • 1 January 1984
    • journal article
    • research article
    • Vol. 25  (12) , 1335-1342
Abstract
Uptake and turnover of 15-(p[123I]iodophenyl)pentadecanoic acid (I-PPA), a radioiodinated free-fatty-acid [FFA] analog, was examined in heart, lung, liver, kidneys and spleen and compared with that of [1-14C]palmitic acid (PA). High cardiac uptake of both I-PPA (4.4% dose/g) and PA (2.8% dose/g) was followed by a 2-component tracer clearance. Kinetics of I-PPA were linked to those of PA in tissue with primary oxidation of FFA or their preferential storage. Tissue lipids of all organs investigated were labeled concordantly by both traces. Fractional distributions of PA and I-PPA incorporation in tissue lipids were significantly correlated. General pathways of FFA tissue metabolism are traced by this radioidionated FFA analog. High-quality metabolic imaging of the heart is possible by means of I-PPA with conventional scintigraphic equipment or cross-sectional imaging with single photon emission computerized tomography facilities.