HYALINE CYTOPLASMIC INCLUSIONS IN HUMAN HEPATOMA - CASE-REPORT

  • 1 January 1977
    • journal article
    • research article
    • Vol. 21  (3) , 469-476
Abstract
A case of hepatoma in a 79 yr old woman is reported. The patient had an enlarged liver and a pathological liver scintigram. Percutaneous liver biopsies were performed with Menghini- and fine needles. The most prominent feature was the presence of hyaline cytoplasmic PAS[periodic acid Schiff]-negative inclusions in liver parenchymal cells. There was no nuclear atypia. EM disclosed 2 types of cytoplasmic changes. One consisted of a lamellar ultrastructure and was interpreted as hyperplasia of smooth surfaced endoplasmic reticulum. The other change consisted of smooth globular nonmembrane limited regions containing amorphous or finely fibrillar material. This was interpreted as corresponding to the hyaline inclusions visible in the light microscope. The presence of PAS negative hyaline cytoplasmic inclusions may be a sign of hepatoma. This may be of relevance for the diagnostic considerations of material obtained by fine needle biopsy.

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