Progressive Cerebral Volume Loss in Human Immunodeficiency Virus Infection
Open Access
- 1 February 1998
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 55 (2) , 161-168
- https://doi.org/10.1001/archneur.55.2.161
Abstract
NEUROCOGNITIVE disorders in human immunodeficiency virus (HIV) disease range in severity from incapacitating HIV-associated dementia to milder but symptomatic HIV-associated minor cognitive-motor disorders to asymptomatic subtle cognitive impairments revealed as deficits only by detailed neuropsychological testing. These neurocognitive disorders seem to be directly caused by HIV in the brain.1-6 Because the neurons are not infected by HIV, the neuronal damage responsible for these conditions is probably due to the neurotoxic products of HIV-infected lymphocytes, macrophages, and microglia.7-9Keywords
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