Acute Myeloid Leukaemia with the Philadelphia Chromosome

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Abstract
A case report of serial chromosome studies on a 26 yr old male with acute myeloid leukemia (AML) is presented. The classic Philadelphia chromosome (Ph1) translocation, t(9;22) was found in 77% of the metaphases at diagnosis and in 100% in relapse; during a 3-mo. remission period, the cytogenetic picture was normal or the Ph1 was present in a minor cell population only. The clinical and morphologic features of this case indicated that it was really a case of AML and less likely chronic myeloid leukemia (CML) presenting in blast crisis. The oncogen producing the 9;22-translocation and CML may also induce AML in rare instances.