The 'metabolic burst' in polymorphonuclear leukocytes from patients with quiescent psoriasis

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Abstract
An investigation of the peripheral blood polymorphonuclear leukocytes (PMN) from untreated patients with mild, quiescent psoriasis was performed. Four aspects of the metabolic burst were measured to illustrate phagocytosis-related events. These were: meyloperoxidase activity H2O2 release, superoxide production and luminol-amplified chemiluminescence. The study does not support the content of an intrinsic abnormality of the PMN in psoriasis, but provides additional evidence for disease activity-dependent changes in phagocytic behavior. Possible interactions with certain humoral factors, the so-called opsonins, are discussed.