Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival.
- 1 April 1996
- journal article
- abstracts
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 14 (4) , 1201-1208
- https://doi.org/10.1200/jco.1996.14.4.1201
Abstract
PURPOSEThe present study serves to describe outcomes-based prognostic variables characteristic of synovial cell sarcoma.PATIENTS AND METHODSAn analysis was performed of a prospectively compiled data base of 48 consecutive patients with extremity and truncal synovial sarcomas seen between 1966 and 1994.RESULTSNo local recurrences were observed among 27 patients who presented with localized primary disease. Patients with synovial sarcoma less than 5 cm in size has a cancer-specific survival rate at 10 years of 100%, compared with a 10-year survival rate of 32% and 0% for those with sarcoma 5 to 10 cm and greater than 10 cm, respectively (P = .002). Patients with synovial sarcoma with less than 10 mitoses per 10 high-power fields (hpf) had a 10-year cancer-specific survival rate of 46%, compared with a 10-year survival rate of 14% for those with sarcomas with greater than 10 mitoses per hpf (P = .04). Patients with a clean margin of excision were found to have a 10-year cancer-specific survival rate of 43%, ...Keywords
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