Total Synthesis of (+)-Crocacin A
- 1 January 2003
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 56 (8) , 783-785
- https://doi.org/10.1071/ch03026
Abstract
The first asymmetric total synthesis of the electron-transport inhibitor crocacin A (1) is described. The key step involved acylation of the anion derived from dienecarbamate (6) with the acid chloride (5) to afford the enamide (14). Desilylation, oxidation, and N-deprotection gave acid (17), which was coupled with glycine methyl ester to afford (1).Keywords
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