The Role of Mechanical Loading in the Onset and Progression of Osteoarthritis
Top Cited Papers
- 1 October 2005
- journal article
- review article
- Published by Wolters Kluwer Health in Exercise and Sport Sciences Reviews
- Vol. 33 (4) , 195-200
- https://doi.org/10.1097/00003677-200510000-00008
Abstract
Osteoarthritis is a progressive joint disease characterized by an imbalance of articular cartilage biosynthesis and degradation attributed to both inflammatory and biomechanical factors. Whereas moderate mechanical loading appears necessary for maintaining healthy cartilage, abnormal joint loading increases the risk of osteoarthritis. Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint.Keywords
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