Insulin-Unresponsive Tissues Respond to Superactive Insulin-Like Material
- 27 June 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 188 (4195) , 1317-1319
- https://doi.org/10.1126/science.1170638
Abstract
Insulin-like material prepared from insulin-Sepharose stimulates glucose oxidation by isolated diaphragm of C57Bl/6J ob/ob mice, but insulin does not. This material is much more effective than insulin on epididymal fat tissue from these mice. Insulin-like material and insulin are equipotent on the corresponding tissues from lean littermates.Keywords
This publication has 7 references indexed in Scilit:
- Structure of a soluble super-active insulin is revealed by the nature of the complex between cyanogen-bromide-activated sepharose and amines.Proceedings of the National Academy of Sciences, 1975
- Super-active forms of placental lactogen and prolactinBiochemical and Biophysical Research Communications, 1974
- A Soluble Super-Active Form of InsulinProceedings of the National Academy of Sciences, 1974
- Amelioration of insulin resistance in obese miceAmerican Journal of Physiology-Legacy Content, 1971
- Hormonal Control of Intermediary Metabolism in Obese Hyperglycemic Mice: I. The Sensitivity and Response to Insulin in Adipose Tissue and Muscle in VitroDiabetes, 1971
- Effect of insulin in vivo on diaphragm and adipose tissue of obese miceAmerican Journal of Physiology-Legacy Content, 1969
- Glucose metabolism and mobilization of fatty acids by adipose tissue from obese miceAmerican Journal of Physiology-Legacy Content, 1961