TREATMENT OF ACUTE-RENAL-FAILURE DUE TO MYELOMA KIDNEY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 123  (8) , 750-753
Abstract
Severe renal insufficiency indicates a poor prognosis in patients with multiple myeloma, their reported median survival being approximately 2 mo. In 5 consecutive patients with severe renal failure secondary to acute myeloma kidney early aggressive therapy, including chemotherapy [vincristine, cyclophosphamide, melphalan, prednisone, 1,3-bis-(2-chlorpethyl)-1-nitrosourea] and peritoneal dialysis, led to a significant improvement in the renal function of 4; the 5th patient received a cadaveric renal transplant after 1 yr of peritoneal dialysis. After a median follow-up period of 12 mo., all the patients were alive and had improved renal function. This experience contrasts with that previously reported and suggests that aggressive management may improve the survival of patients with acute renal failure due to myeloma kidney.

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