MYOCARDIAL DEPRESSION ASSOCIATED WITH EFFECTIVE REFRACTORY PERIOD PROLONGATION AFTER PENTOBARBITAL AND PROCAINAMIDE BUT NOT AFTER DANTROLENE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 28  (1) , 13-26
Abstract
Effective refractory period (ERP) and contractile force (CF) of isolated rabbit left atria were monitored before and during cumulative concentration-response curves to procainamide [PC], pentobarbital [PB] and dantrolene [DT]. CF reductions and ERP increases were observed after addition of PB or PC. DT atypically reduced CF without affecting ERP. The prolonged ERP correlated with simultaneous CF reductions during PB and PC activity. The sarcolemmal stabilizing effects of PB and PC could be related to CF reductions, while the cardiac depression of DT is apparently unrelated to this action and, as in skeletal muscle, may result from intracellular activity.

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