ISOLATION OF 3RD COMPONENT OF MOUSE COMPLEMENT

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 118  (3) , 1032-1035
Abstract
The 3rd component of mouse complement (C3) was purified to homogeneity from pseudoglobulin by 2 chromatographic steps involving sequential cation- and anion-exchange chromatography. Mouse C3 is a .beta.-glycoprotein of MW 210,000 consisting of 2 nonidentical, disulfide-linked polypeptide chains of MW 130,000 and 75,000, respectively. The properties of this molecule and its proteolytic fragments closely resemble those of human C3.

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