Aureomycin in Experimental Polyarthritis with Preliminary Trials in Clinical Arthritis

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Abstract
Aureomycin mixed with Purina dog chow in concns. of 0.1% or 0.3% afforded complete protection from polyarthritis of all rats infected with a pleuropneumonia-like organism. Intubation of fasting infected rats with 50 mg./kg. for 2 days resulted in a 20% incidence of arthritis and an avg. arthrogram score of 0.4; a single subcut. dose of 100 mg./kg. of aureomycin gave an arthritis incidence of 20% and an arthrogram score of 0.3, whereas controls showed an arthritis incidence of 77.4% with an avg. arthrogram score of 2.41. Injn. of 100 mg./kg. of aureomycin 7 and 8 days after infection had a curative effect as shown by a marked decrease in incidence of arthritis and a decreased avg. arthrogram score. In vitro concns. of 3 [mu]g./ml. of broth prevented growth of pleuropneumonia-like organisms. Blood level concns. in rats eating a diet of 0.1% and 0.075% aureomycin were 0.62 [mu]g./ml. and less than 0.155 [mu]g./ml., resp. Intubation of 50 mg./kg- resulted in a blood concn. of 0.62 [mu]g./ml. 2 hrs. after admn. In preliminary clinical trials, several patients with chronic rheumatoid arthritis failed to respond to aureomycin therapy. One case of Reiter''s syndrome responded by wt. gain, decreased joint swelling and a fall in erythrocyte sedimentation rate.

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