Interrelationships of glutathione reductase, 5‐aminolevulinic acid dehydratase, and free sulfhydryl groups in the erythrocytes of normal and lead‐exposed persons

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Abstract
Blood lead, erythrocyte glutathione reductase (GSSG‐R), 5‐aminolevulinic acid dehydratase (ALA‐D), and free sulfhydryl (SH) groups were measured in normal subjects and in those with occupational exposure to lead. With increasing blood lead concentration the activity of GSSG‐R rises and that of ALA‐D decreases. There is also a fall in the level of free SH with rising blood lead concentrations. There is a high degree of correlation between these parameters, and it is suggested that the changes represent part of a biological control mechanism to compensate for the reduction of available sulfhydryl groups by lead ions.