RENAL FUNCTION DURING PREGNANCY COMPLICATED BY INTERCAPILLARY GLOMERULOSCLEROSIS: SERIAL STUDIES IN A YOUNG DIABETIC

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Abstract
[Interlingua summ.]Serial renal function studies have been carried out during pregnancy in a 22-year-old woman with juvenile diabetes of 18 years duration. At the onset of pregnancy there were labile hypertension, moderate proteinuria, mild retinopathy, and diffuse intercapillary glomerulosclerosis on renal biopsy. The clinical course was favorable, and the retinopathy improved until just prior to delivery. During pregnancy there was increase of renal function similar to that seen in normal pregnant subjects. The glomerular filtration rate rose to 150 ml/min. by the 24th week of pregnancy, and the estimated renal plasma flow to 1000 ml/ minute, both values roughly 50% above the normal mean for non-pregnant subjects, and the filtration fraction, initially reduced to 0.11, became normal and remained so during the postpartum period. Tubular reabsorption of glucose was not increased concomitantly with the increase in filtration, so that glycosuria was possible in the face of lower concentrations of glucose in the plasma.

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